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Without stimulating medications, the ovaries make and release only 1 mature egg per menstrual cycle (month).

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Estrogens should be used at the lowest dose possible for your treatment only as long as needed.

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In 2002, the Women's Health Initiative terminated a study of combined hormone replacement therapy prematurely because participants displayed a higher than normal risk of serious side effects: breast cancer, heart disease, stroke and blood clots.

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Headache is one of the more common estradiol side effects and may affect up to 20% of people who take it.

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