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Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology.

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Review of role of rifapentin, a cyclopentyl substituted semisynthetic rifamycin with similar activity and resistance pattern to rifampin, but longer half-life allowing for once weekly therapy; efficacy may be slightly less than rifampin and it is recommended only in selected patients; side effects are similar to rifampin).

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Resistance to the sulfones was first described in the mid-1960s and resistance to rifampicin in the early 1970s.

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Indeed, this was previously the recommended standard regimen in many countries until the early 1990s, when isoniazid-resistance rates increased.

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Tuberculosis (TB) is no exception: in 2012, there were an estimated 450 000 cases of multidrug-resistant (MDR) TB, which is defined as disease caused by strains of Mycobacterium tuberculosis ( Mtb) that are resistant to the frontline anti-TB drugs, isoniazid (INH) and rifampicin (RIF).

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When a person is infected with pulmonary tuberculosis, the bacteria in the lungs multiply and cause pneumonia along with chest pain, hemoptysis and a prolonged cough.

This overuse is starting to concern many people, as new super germs that are antibiotic resistant continue to develop.

Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates.

It is because we have limited resources for extra-pulmonary TB.

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Sulfonamides and several broad-spectrum antibiotic compounds may augment the anticoagulant effect of warfarin in patients consuming diets deficient in vitamin K by eliminating bacterial flora and aggravating vitamin K deficiency.

Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in the Netherlands.

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In one type of reaction, immune cells crowd into the area in an attempt to seal off the bacterium, and in these areas very few bacilli can be found.

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